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S is a key protein in the pathology of Parkinsons disease (PD) [253], characterized by the loss of dopaminergic neuronal cells in the substantia nigra pars compacta and the abnormal accumulation and aggregation of S in the form of Lewy bodies and Lewy neurites

Tsimberidou A, Thomas DA, OBrien S, Andreeff M , Kurzrock R, Keating M, Albitar M, Kantarjian HM, Giles FJ

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While ROS can function as second messengers regulating cellular reproduction, growth, differentiation, and signaling when maintained at optimal concentrations and dynamic equilibrium, exceeding critical ROS thresholds induces oxidative stress, leading to DNA damage, protein denaturation, and lipid peroxidationkey factors in CHD development

ALS is typically a late onset disease with a mean age of onset at 64 years old (Marin et al., 2016)

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